Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.51 |
| ▸ | BRAF | P15056 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | P2RY1 | P47900 | 3/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PPIF | P30405 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660918 | 0.84 | BRAF (0.57) | BRAFKDRP2RY1 | |
| SCHEMBL5880620 | 0.84 | BRAF (0.66) | MAPK14BRAFKDRPDGFRAKIT | |
| SCHEMBL1660260 | 0.81 | MAPK14 (0.60) | MAPK14BRAFKDRPDGFRAKIT | |
| SCHEMBL1660380 | 0.80 | NPC1 (0.47) | BRAFKDRP2RY1PDGFRAKIT | |
| SCHEMBL1660418 | 0.75 | MAPK14 (0.54) | MAPK14BRAFKDRPDGFRAKIT | |
| SCHEMBL27711531 | 0.74 | SMN1; SMN2 (0.44) | KDRKMT2ARAB9A | |
| SCHEMBL1661876 | 0.74 | MAPK14 (0.71) | MAPK14BRAFKDRPDGFRAKIT | |
| SCHEMBL2559430 | 0.73 | BRAF (0.72) | MAPK14BRAFKDRPDGFRAKIT | |
| SCHEMBL11001744 | 0.72 | TAS1R3 (0.58) | MEN1KMT2ARAB9A | |
| SCHEMBL1662382 | 0.72 | DDR2 (0.51) | MAPK14BRAFKDRPDGFRAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | claimed |