Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SLC5A1 | P13866 | 3/20 | 0.49 |
| ▸ | SLC5A2 | P31639 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11397439 | 0.88 | KEAP1 (0.52) | CYP19A1SLC5A1SLC5A2GAAMAPT | |
| SCHEMBL14141727 | 0.82 | CYP19A1 (0.42) | CYP19A1MEN1KMT2AGAAMAPT | |
| SCHEMBL1841587 | 0.81 | CYP19A1 (1.00) | CYP19A1MEN1KMT2ASLC5A1SLC5A2 | |
| SCHEMBL8800760 | 0.78 | CYP19A1 (0.39) | CYP19A1MEN1KMT2AGAAMAPT | |
| SCHEMBL210134 | 0.76 | HPGD (0.44) | CYP19A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL1076586 | 0.74 | DPP4 (0.67) | CYP19A1MEN1KMT2ASLC5A1SLC5A2 | |
| SCHEMBL10936614 | 0.73 | KDM6B (0.51) | CYP19A1KDM4ELMNACYP1A2CYP3A4 | |
| SCHEMBL4164418 | 0.73 | CYP19A1 (0.61) | CYP19A1MEN1KMT2ASLC5A1SLC5A2 | |
| SCHEMBL7044239 | 0.73 | LIG1 (0.61) | CYP19A1MEN1KMT2AGAAMAPT | |
| SCHEMBL936740 | 0.72 | HTT (0.47) | MEN1KMT2AMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491051-A2 | GADD45BETA TARGETING AGENTS | Imperial Innovations Limited (GB) | 2012-08-29 | — | — | EP | claimed |
| WO-2011048390-A2 | GADD45BETA TARGETING AGENTS | IMPERIAL INNOVATIONS LIMITED (GB) | 2011-04-28 | — | — | WO | claimed |
| US-4686283-A | POLYPEPTIDES | SYNTEX (U.S.A.) INC. (US) | 1987-08-11 | — | — | US | disclosed |