SCHEMBL16612057

SCHEMBL16612057

COc1cc(C)cc2sc(C)cc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.45
ERN1 O75460 1/20 0.34
MAPT P10636 1/20 0.34
TSHR P16473 1/20 0.34
ALDH1A1 P00352 3/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CA2 P00918 1/20 0.33
CNR2 P34972 4/20 0.33
HDAC3 O15379 1/20 0.32
HDAC4 P56524 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC10 Q969S8 1/20 0.32
HDAC11 Q96DB2 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
HDAC9 Q9UKV0 1/20 0.32
HDAC5 Q9UQL6 1/20 0.32
MALT1 Q9UDY8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24447297 0.74 CA2 (0.57) MAPTTSHRALDH1A1SMN1; SMN2CA2
SCHEMBL17345875 0.74 HSD17B10 (0.39) MAPTALDH1A1SMN1; SMN2
SCHEMBL15424071 0.73 ACHE (0.62) ACHEERN1MAPTALDH1A1SMN1; SMN2
SCHEMBL21983452 0.72 ALDH1A1 (0.35) ALDH1A1
SCHEMBL22132793 0.68 ACHE (0.45) ACHEERN1
SCHEMBL13556361 0.67 STING1 (0.46) ACHEALDH1A1HDAC3HDAC4HDAC1
SCHEMBL20049214 0.65 MAPT (0.53) ACHEMAPTTSHRALDH1A1SMN1; SMN2
SCHEMBL13885546 0.65 NQO1 (0.47) ACHEMAPTTSHRALDH1A1CA2
SCHEMBL2611542 0.65 ACHE (0.65) ACHEERN1MAPTALDH1A1SMN1; SMN2
SCHEMBL15281129 0.64 ALDH1A1 (0.39) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3647311-B1 RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF BEIJING TIDE PHARMACEUTICAL CO LTD (CN) 2023-11-01 EP disclosed
EP-3932404-A1 METHOD FOR TREATING FATTY LIVER DISEASE AND/OR STEATOHEPATITIS Beijing Tide Pharmaceutical Co., Ltd. (CN) 2022-01-05 EP disclosed
EP-3647311-A1 RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND PREPARATION METHOD AND USE THEREOF Beijing Tide Pharmaceutical Co., Ltd. (CN) 2020-05-06 EP disclosed
EP-2857388-A1 Azoles containing sulfone Grünenthal GmbH (DE) 2015-04-08 EP disclosed