Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.51 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119149 | 0.80 | MAPT (0.56) | MAPTMEN1KMT2APOLBABCG2 | |
| SCHEMBL16612291 | 0.80 | MAPT (0.56) | MAPTMEN1KMT2APOLBABCG2 | |
| SCHEMBL32666085 | 0.78 | KDM4E (0.61) | MAPTMEN1KMT2APOLBAKR1C3 | |
| SCHEMBL6179431 | 0.77 | AKR1C3 (0.74) | MAPTMEN1KMT2APOLBAKR1C3 | |
| SCHEMBL16611908 | 0.74 | SHMT2 (0.53) | MAPTMEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL3108501 | 0.74 | NPY5R (0.72) | MAPTMEN1KMT2APOLBABCG2 | |
| SCHEMBL11380868 | 0.74 | AKR1C3 (0.58) | MAPTMEN1KMT2APOLBAKR1C3 | |
| SCHEMBL31220866 | 0.72 | MEN1 (0.68) | MAPTMEN1KMT2APOLBAKR1C3 | |
| SCHEMBL6178670 | 0.71 | ALDH1A1 (0.57) | MAPTMEN1KMT2AAKR1C3AKR1C2 | |
| SCHEMBL3113501 | 0.71 | MAPT (0.53) | MAPTMEN1KMT2APOLBABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857393-B1 | N-ARYL UNSATURATED FUSED RING TERTIARY AMINE COMPOUND, PREPARATION METHOD THEREOF AND ANTITUMOR APPLICATION THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2018-09-12 | — | — | EP | disclosed |
| US-9751884-B2 | N-aryl unsaturated fused ring tertiary amine compounds, preparation method and anti-tumor applications thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2017-09-05 | — | — | US | disclosed |
| US-20150141407-A1 | N-Aryl Unsaturated Fused Ring Tertiary Amine Compounds, Preparation Method and Anti-Tumor Applications Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2015-05-21 | — | — | US | disclosed |
| EP-2857393-A1 | N-ARYL UNSATURATED FUSED RING TERTIARY AMINE COMPOUND, PREPARATION METHOD THEREOF AND ANTITUMOR APPLICATION THEREOF | Institute Of Pharmacology And Toxicology Academy Of Militaty Medical Sciences P.L.A. (CN) | 2015-04-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141407-A1 | N-Aryl Unsaturated Fused Ring Tertiary Amine Compounds, Preparation Method and Anti-Tumor Applications Thereof | H1-0, H1-5, H1-3 | MAPT 3427/4885MEN1 746/4885KMT2A 1467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.