Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612864 | 0.84 | MEN1 (0.47) | MAPTLMNARAB9ANPC1HDAC1 | |
| SCHEMBL16612830 | 0.83 | MEN1 (0.47) | MAPTLMNAHDAC1HDAC2ALDH1A1 | |
| SCHEMBL16613012 | 0.82 | MAPT (0.49) | MAPTLMNAHDAC1HDAC2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL21491574 | 0.81 | MAOB (0.48) | MAPTLMNARAB9ANPC1ATM | |
| Hydrochloric Acid SCHEMBL28525348 | 0.77 | HCRTR2 (0.48) | MAPTRAB9ANPC1HDAC1HDAC2 | |
| SCHEMBL12479353 | 0.74 | MEN1 (0.64) | MAPTLMNARAB9ANPC1ALDH1A1 | |
| SCHEMBL12479530 | 0.74 | MAOB (0.50) | MAPTRAB9ANPC1ALDH1A1MAOB | |
| SCHEMBL21251534 | 0.74 | HDAC2 (0.50) | MAPTRAB9ANPC1ATMHDAC1 | |
| SCHEMBL12479474 | 0.72 | MAPT (0.48) | MAPTLMNAALDH1A1PKML3MBTL1 | |
| SCHEMBL3611556 | 0.72 | MAPT (0.97) | MAPTLMNARAB9ANPC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |