Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 4/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12479353 | 0.84 | MEN1 (0.64) | MEN1KMT2AHCRTR2MAPTLMNA | |
| SCHEMBL16612776 | 0.83 | MAPT (0.55) | MEN1KMT2AHCRTR2HDAC1HDAC2 | |
| SCHEMBL16612864 | 0.83 | MEN1 (0.47) | MEN1KMT2AHDAC1HDAC2MAPT | |
| SCHEMBL12479925 | 0.76 | MAPT (0.50) | MEN1KMT2AHCRTR2MAPTLMNA | |
| SCHEMBL16613012 | 0.75 | MAPT (0.49) | MEN1KMT2AHCRTR2HDAC1HDAC2 | |
| SCHEMBL12479530 | 0.73 | MAOB (0.50) | MEN1KMT2AHCRTR2MAPTALDH1A1 | |
| SCHEMBL3616273 | 0.73 | MAPT (0.65) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL21523747 | 0.71 | MAPT (0.68) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL16612785 | 0.70 | HCRTR2 (0.46) | MEN1KMT2AHCRTR2MAPTLMNA | |
| Fluorobenzene SCHEMBL27885840 | 0.70 | MAPT (0.53) | MEN1KMT2AMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |