Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 8/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612851 | 0.83 | HCRTR2 (0.44) | MAPTLMNAHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL16612776 | 0.82 | MAPT (0.55) | MAPTLMNAHCRTR2ALDH1A1PKM | |
| SCHEMBL12479474 | 0.76 | MAPT (0.48) | MAPTLMNAHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL16612830 | 0.75 | MEN1 (0.47) | MAPTLMNAHCRTR2ALDH1A1PKM | |
| SCHEMBL16612864 | 0.73 | MEN1 (0.47) | MAPTLMNAALDH1A1PKML3MBTL1 | |
| SCHEMBL16613040 | 0.72 | HCRTR1 (0.45) | MAPTLMNAHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL16612785 | 0.72 | HCRTR2 (0.46) | MAPTLMNAHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL16612991 | 0.72 | HCRTR2 (0.47) | MAPTLMNAHCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL15140101 | 0.71 | KDM4E (0.47) | ALDH1A1L3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL1663037 | 0.70 | MEN1 (0.45) | MAPTLMNAALDH1A1PKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |