Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 2/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612946 | 0.86 | ADORA2A (0.44) | KDM4EKMOADORA2AMEN1ALDH1A1 | |
| SCHEMBL5546097 | 0.84 | ADORA2A (0.54) | KDM4EMAPTNR4A1NR4A2NR4A3 | |
| SCHEMBL15189624 | 0.83 | MEN1 (0.46) | KDM4EKMOKDM5AKDM4CKDM5B | |
| SCHEMBL16613030 | 0.83 | KMO (0.42) | KDM4EKMONR4A2NOTUMADORA2A | |
| SCHEMBL16612941 | 0.83 | IP6K1 (0.46) | KDM4EKMONOTUMPIN1SMN1; SMN2 | |
| SCHEMBL17746046 | 0.82 | MAPK14 (0.45) | KDM4EKDM5AKDM4CKDM5BNOTUM | |
| SCHEMBL16612913 | 0.81 | NOTUM (0.45) | NOTUMADORA2AHCRTR2HPGDSPIN1 | |
| SCHEMBL15189706 | 0.81 | GSK3B (0.51) | KDM4EMAPTNOTUMPIN1SMN1; SMN2 | |
| SCHEMBL16612958 | 0.81 | STK17B (0.43) | KDM4EFFAR1MEN1ALDH1A1CYP1A2 | |
| SCHEMBL16612964 | 0.80 | NOTUM (0.44) | KDM4EMAPTNOTUMADORA2AHCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440555-B1 | FLUORINATED AMINOTRIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2016-05-18 | — | — | EP | claimed |
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | claimed |