Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 7/20 | 0.47 |
| ▸ | KYAT1 | Q16773 | 2/20 | 0.47 |
| ▸ | KYAT3 | Q6YP21 | 2/20 | 0.47 |
| ▸ | GOT1 | P17174 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 3/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613090 | 0.81 | AADAT (0.52) | AADATKYAT1KYAT3GOT1ALDH1A1 | |
| SCHEMBL7419579 | 0.74 | AADAT (0.51) | AADATKYAT1KYAT3GOT1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1239293 | 0.74 | AADAT (0.51) | AADATKYAT1KYAT3GOT1 | |
| SCHEMBL16613079 | 0.73 | AADAT (0.44) | AADATKYAT1KYAT3GOT1ALDH1A1 | |
| SCHEMBL14170038 | 0.73 | AADAT (0.59) | AADATKYAT1KYAT3GOT1 | |
| SCHEMBL4801687 | 0.73 | AADAT (0.59) | AADATKYAT1KYAT3GOT1 | |
| SCHEMBL9198224 | 0.72 | AADAT (0.49) | AADATKYAT1KYAT3GOT1 | |
| Hydrochloric Acid SCHEMBL7416859 | 0.72 | AADAT (0.58) | AADATKYAT1KYAT3GOT1 | |
| SCHEMBL7422259 | 0.71 | AADAT (0.47) | AADATKYAT1KYAT3GOT1KDM4E | |
| SCHEMBL9200143 | 0.71 | AADAT (0.44) | AADATKYAT1KYAT3GOT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443092-B1 | BICYCLIC AND TRICYCLIC COMPOUNDS AS KAT II INHIBITORS | PFIZER (US) | 2015-04-08 | — | — | EP | disclosed |