Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 13/20 | 1.00 |
| ▸ | KYAT3 | Q6YP21 | 3/20 | 0.46 |
| ▸ | KYAT1 | Q16773 | 2/20 | 0.46 |
| ▸ | GOT1 | P17174 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3779303 | 1.00 | AADAT (1.00) | AADATKYAT3KYAT1GOT1NOTUM | |
| SCHEMBL3786010 | 1.00 | AADAT (1.00) | AADATKYAT3KYAT1GOT1NOTUM | |
| Hydrochloric Acid SCHEMBL16612967 | 0.98 | AADAT (0.97) | AADATKYAT3KYAT1GOT1NOTUM | |
| Hydrochloric Acid SCHEMBL16612968 | 0.98 | AADAT (0.97) | AADATKYAT3KYAT1GOT1NOTUM | |
| Hydrochloric Acid SCHEMBL16612966 | 0.98 | AADAT (0.97) | AADATKYAT3KYAT1GOT1NOTUM | |
| SCHEMBL6971389 | 0.78 | AADAT (0.64) | AADATKYAT3KYAT1GOT1NOTUM | |
| SCHEMBL31381632 | 0.78 | AADAT (0.64) | AADATKYAT3KYAT1GOT1NOTUM | |
| SCHEMBL4885859 | 0.78 | AADAT (0.64) | AADATKYAT3KYAT1GOT1GAA | |
| SCHEMBL22631177 | 0.74 | AADAT (0.58) | AADATKYAT3KYAT1GOT1NOTUM | |
| SCHEMBL3774105 | 0.71 | AADAT (0.55) | AADATGAAMAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443092-B1 | BICYCLIC AND TRICYCLIC COMPOUNDS AS KAT II INHIBITORS | PFIZER (US) | 2015-04-08 | — | — | EP | claimed |