Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662293 | 0.85 | CYP1A2 (0.41) | KDM4EHSD17B10PPARGMTNR1AMTNR1B | |
| SCHEMBL5777259 | 0.81 | SMN1; SMN2 (0.40) | SIRT1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL1661108 | 0.81 | ALDH1A1 (0.39) | KDM4EALDH1A1MAPTHSD17B10MTNR1A | |
| Water SCHEMBL30025993 | 0.79 | LOXL2 (0.55) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL5777838 | 0.79 | SMN1; SMN2 (0.50) | SIRT1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL2562389 | 0.79 | RHEB (0.36) | SIRT1MTNR1AMTNR1BLOXL2 | |
| SCHEMBL693847 | 0.78 | PYGL (0.42) | KDM4EMAPTKMT2ANLRP3SMN1; SMN2 | |
| SCHEMBL49270 | 0.77 | LOXL2 (0.56) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL31336079 | 0.77 | LOXL2 (0.56) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL29365671 | 0.77 | LOXL2 (0.56) | KDM4EALDH1A1MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306994-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | Amgen, Inc (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |