Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.40 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.40 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL615858 | 0.87 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPTALDH1A1TUBB4ATUBB | |
| SCHEMBL30480756 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTALDH1A1TUBB4ATUBB | |
| SCHEMBL616022 | 0.85 | SMN1; SMN2 (0.44) | SMN1; SMN2MAPTALDH1A1TUBB4ATUBB | |
| SCHEMBL16599955 | 0.83 | ALDH1A1 (0.41) | SMN1; SMN2MAPTALDH1A1GSTO1HIF1A | |
| SCHEMBL30480741 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTALDH1A1TUBB4ATUBB | |
| SCHEMBL613835 | 0.81 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTALDH1A1TUBB4ATUBB | |
| SCHEMBL18690075 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTALDH1A1TUBB4ATUBB | |
| SCHEMBL615839 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTTUBB4ATUBBTUBA3C | |
| SCHEMBL850626 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL16648344 | 0.74 | ALDH1A1 (0.69) | SMN1; SMN2MAPTALDH1A1HIF1ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160229839-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-08-11 | — | — | US | disclosed |
| US-20160229839-A1 | Factor XIa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-08-11 | — | — | US | disclosed |
| WO-2015047973-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229839-A1 | Factor XIa Inhibitors | F11, SERPINC1, TFPI | SMN1; SMN2 4591/4885MAPT 3611/4885ALDH1A1 3635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.