Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2851983 | 0.82 | ALDH1A1 (0.61) | ALDH1A1NPSR1HSP90AA1MAPK1MAPT | |
| SCHEMBL16615588 | 0.81 | ALDH1A1 (0.66) | ALDH1A1NPSR1HSP90AA1MAPK1MAPT | |
| SCHEMBL16615651 | 0.78 | ALDH1A1 (1.00) | ALDH1A1NPSR1HSP90AA1MAPK1MAPT | |
| SCHEMBL2852994 | 0.77 | ALDH1A1 (0.56) | ALDH1A1NPSR1HSP90AA1MAPK1MAPT | |
| SCHEMBL10365422 | 0.77 | MAPT (0.67) | ALDH1A1MAPTSMN1; SMN2POLBKDM4E | |
| SCHEMBL2854667 | 0.77 | ALDH1A1 (0.55) | ALDH1A1NPSR1HSP90AA1MAPK1MAPT | |
| SCHEMBL10852384 | 0.75 | MAPT (0.64) | ALDH1A1NPSR1MAPTSMN1; SMN2POLB | |
| SCHEMBL10365006 | 0.73 | MAPT (0.72) | ALDH1A1NPSR1MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL2853095 | 0.73 | ALDH1A1 (0.58) | ALDH1A1NPSR1HSP90AA1MAPK1MAPT | |
| SCHEMBL2857362 | 0.72 | ALDH1A1 (0.49) | ALDH1A1NPSR1HSP90AA1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10092574-B2 | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof | VALORISATION-RECHERCHE, LIMITED PARTNERSHIP (CA) | 2018-10-09 | — | — | US | disclosed |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | Université de Montréal (CA) | 2016-07-28 | — | — | US | disclosed |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | Université de Montréal (CA) | 2016-07-28 | — | — | US | disclosed |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | Université de Montréal (CA) | 2016-07-28 | — | — | US | disclosed |
| WO-2015042685-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | VALORISATION-RECHERCHE (CA) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10092574-B2 | Inhibitors of polynucleotide repeat-associated RNA foci and uses thereof | FBL, HNRNPA1, HNRNPUL1 | ALDH1A1 4383/4885NPSR1 3361/4885HSP90AA1 1596/4885 |
| US-20160213679-A1 | INHIBITORS OF POLYNUCLEOTIDE REPEAT-ASSOCIATED RNA FOCI AND USES THEREOF | FBL, HNRNPA1, HNRNPUL1 | ALDH1A1 4383/4885NPSR1 3361/4885HSP90AA1 1596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.