Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.56 |
| ▸ | CES1 | P23141 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 2/20 | 0.51 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16618394 | 0.80 | HPGD (0.54) | PARP1MEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL2540656 | 0.77 | CES2 (0.67) | CES2CES1PARP1STSHSD17B2 | |
| SCHEMBL30870831 | 0.77 | CES2 (0.67) | CES2CES1PARP1STSHSD17B2 | |
| SCHEMBL12989210 | 0.76 | CES2 (0.61) | CES2CES1PARP1STSHSD17B2 | |
| SCHEMBL2199255 | 0.76 | CES2 (0.65) | CES2CES1PARP1STSHSD17B2 | |
| SCHEMBL14319078 | 0.75 | CES2 (0.59) | CES2CES1PARP1STSHSD17B2 | |
| SCHEMBL307622 | 0.74 | CES2 (0.62) | CES2CES1PARP1STSHSD17B2 | |
| SCHEMBL27816171 | 0.74 | CES2 (0.57) | CES2CES1PARP1STSHSD11B1 | |
| SCHEMBL8339920 | 0.73 | CES2 (0.71) | CES2CES1PARP1STSNPC1 | |
| SCHEMBL12084023 | 0.73 | CES2 (0.61) | CES2CES1PARP1STSHSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051043-A1 | BIARYL ACYL-SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. (US) | 2015-04-09 | — | — | WO | disclosed |