Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11910523 | 0.81 | HPGD (0.56) | HPGDTDP1PARP1HDAC8HDAC6 | |
| SCHEMBL365237 | 0.80 | HSD11B1 (0.50) | HPGDKMT2APOLB | |
| SCHEMBL16618343 | 0.80 | CES2 (0.56) | PARP1SMN1; SMN2MEN1KMT2AKAT6A | |
| SCHEMBL9100257 | 0.79 | HPGD (0.61) | HPGDTDP1PARP1HDAC8HDAC6 | |
| SCHEMBL15011166 | 0.77 | HPGD (0.59) | HPGDTDP1PARP1HDAC8HDAC6 | |
| SCHEMBL6832775 | 0.75 | HPGD (0.61) | HPGDTDP1PARP1HDAC8HDAC6 | |
| SCHEMBL1759401 | 0.74 | HPGD (0.65) | HPGDTDP1PARP1HDAC8HDAC6 | |
| SCHEMBL29637011 | 0.74 | HPGD (0.65) | HPGDTDP1PARP1HDAC8HDAC6 | |
| SCHEMBL23782 | 0.74 | HPGD (0.65) | HPGDTDP1PARP1HDAC8HDAC6 | |
| SCHEMBL11675937 | 0.73 | HPGD (0.62) | HPGDTDP1PARP1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051043-A1 | BIARYL ACYL-SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. (US) | 2015-04-09 | — | — | WO | disclosed |