Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL134145 | 0.89 | HSD11B1 (0.67) | ALDH1A1HPGDHSD11B1KDM4EL3MBTL1 | |
| SCHEMBL2047793 | 0.79 | HPGD (0.63) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL24992899 | 0.78 | HSD11B1 (0.44) | MAPTALDH1A1HPGDHSD11B1SMN1; SMN2 | |
| SCHEMBL23169174 | 0.77 | MAPT (0.61) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL5858450 | 0.76 | MAPT (0.59) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL7736889 | 0.75 | CES2 (0.52) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL2469395 | 0.74 | KMT2A (0.66) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL30268201 | 0.74 | NPSR1 (0.66) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL9001632 | 0.74 | OXTR (0.64) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL16291493 | 0.74 | KMT2A (0.51) | ALDH1A1HPGDHSD11B1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051043-A1 | BIARYL ACYL-SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. (US) | 2015-04-09 | — | — | WO | disclosed |