Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.46 |
| ▸ | PRKDC | P78527 | 5/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.39 |
| ▸ | KRAS | P01116 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.38 |
| ▸ | MAP3K8 | P41279 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 2/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16619390 | 1.00 | EGFR (0.46) | EGFRPRKDCSOS1KRASERBB2 | |
| SCHEMBL16619574 | 0.86 | EGFR (0.39) | EGFRPRKDCSOS1KRAS | |
| SCHEMBL16619572 | 0.86 | EGFR (0.39) | EGFRPRKDCSOS1KRAS | |
| SCHEMBL16618740 | 0.86 | EGFR (0.51) | EGFRPRKDCSOS1KRASERBB2 | |
| SCHEMBL16618743 | 0.86 | EGFR (0.51) | EGFRPRKDCSOS1KRASERBB2 | |
| SCHEMBL16618856 | 0.85 | EGFR (0.42) | EGFRPRKDCSOS1KRASERBB2 | |
| SCHEMBL16618852 | 0.85 | EGFR (0.42) | EGFRPRKDCSOS1KRASERBB2 | |
| SCHEMBL16619179 | 0.82 | EGFR (0.45) | EGFRPRKDCSOS1KRASMAP3K8 | |
| SCHEMBL16619177 | 0.82 | EGFR (0.45) | EGFRPRKDCSOS1KRASMAP3K8 | |
| SCHEMBL16619646 | 0.80 | EGFR (0.45) | EGFRPRKDCSOS1KRASTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049629-A1 | IMIDAZOQUINOLINE COMPOUNDS AS BROMODOMAIN INHIBITORS | Piramal Enterprises Limited (IN) | 2015-04-09 | — | — | WO | disclosed |