Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 5/20 | 0.42 |
| ▸ | KRAS | P01116 | 4/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.41 |
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16618852 | 1.00 | EGFR (0.42) | EGFRSOS1KRASERBB2PRKDC | |
| SCHEMBL16618740 | 0.89 | EGFR (0.51) | EGFRSOS1KRASERBB2PRKDC | |
| SCHEMBL16618743 | 0.89 | EGFR (0.51) | EGFRSOS1KRASERBB2PRKDC | |
| SCHEMBL16618815 | 0.86 | EGFR (0.39) | EGFRSOS1KRASERBB2HDAC3 | |
| SCHEMBL16618812 | 0.86 | EGFR (0.39) | EGFRSOS1KRASERBB2HDAC3 | |
| SCHEMBL16619392 | 0.85 | EGFR (0.46) | EGFRSOS1KRASERBB2PRKDC | |
| SCHEMBL16619390 | 0.85 | EGFR (0.46) | EGFRSOS1KRASERBB2PRKDC | |
| SCHEMBL16619646 | 0.81 | EGFR (0.45) | EGFRSOS1KRASPRKDCTNF | |
| SCHEMBL16619642 | 0.81 | EGFR (0.45) | EGFRSOS1KRASPRKDCTNF | |
| SCHEMBL16618922 | 0.80 | BRD4 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015049629-A1 | IMIDAZOQUINOLINE COMPOUNDS AS BROMODOMAIN INHIBITORS | Piramal Enterprises Limited (IN) | 2015-04-09 | — | — | WO | disclosed |