Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | PPOX | P50336 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPD | P32754 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.45 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16961927 | 0.84 | HPD (0.50) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL28865598 | 0.83 | AKR1B1 (0.51) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL16956988 | 0.79 | HPD (0.49) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL16031334 | 0.78 | TTR (0.64) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL16956851 | 0.78 | HPD (0.45) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL9018719 | 0.77 | AKR1B1 (0.46) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL27370615 | 0.77 | CFTR (0.56) | TDP1MEN1TTRPPOXKMT2A | |
| SCHEMBL3778792 | 0.74 | MAPK1 (0.55) | TDP1MAPK1AKR1B1AKR1C4AKR1C3 | |
| SCHEMBL30822033 | 0.74 | MAPK1 (0.55) | TDP1MAPK1AKR1B1AKR1C4AKR1C3 | |
| SCHEMBL4658862 | 0.74 | HPD (0.62) | TDP1MEN1KMT2AHPDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052495-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | Pfizer Inc. (US) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015049616-A1 | NOVEL BICYCLIC PYRIDINONES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2015-04-09 | — | — | WO | disclosed |