SCHEMBL16620673

SCHEMBL16620673

Cc1ccc(C=Nc2ccccc2C#N)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.71
ALDH1A1 P00352 9/20 0.57
KDM4E B2RXH2 7/20 0.51
GAA P10253 5/20 0.51
HPGD P15428 5/20 0.51
USP2 O75604 3/20 0.51
SMN1; SMN2 Q16637 5/20 0.49
KMT2A Q03164 5/20 0.49
MEN1 O00255 4/20 0.49
RAB9A P51151 2/20 0.42
NPC1 O15118 1/20 0.42
TSHR P16473 1/20 0.41
MAPT P10636 4/20 0.39
CHAT P28329 1/20 0.39
POLB P06746 1/20 0.38
CASP1 P29466 1/20 0.38
BRCA1 P38398 1/20 0.38
HSD17B10 Q99714 1/20 0.38
SPHK2 Q9NRA0 1/20 0.38
SPHK1 Q9NYA1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16620671 1.00 LMNA (0.71) LMNAALDH1A1KDM4EGAAHPGD
SCHEMBL11587787 0.86 LMNA (0.75) LMNAALDH1A1KDM4EGAAHPGD
SCHEMBL11796171 0.86 LMNA (0.75) LMNAALDH1A1KDM4EGAAHPGD
SCHEMBL16620590 0.84 LMNA (0.59) LMNAALDH1A1KDM4EGAAHPGD
SCHEMBL16620588 0.84 LMNA (0.59) LMNAALDH1A1KDM4EGAAHPGD
SCHEMBL10410005 0.83 LMNA (0.66) LMNAALDH1A1KDM4EHPGDSMN1; SMN2
SCHEMBL10410006 0.83 LMNA (0.66) LMNAALDH1A1KDM4EHPGDSMN1; SMN2
SCHEMBL8619952 0.83 LMNA (0.66) LMNAALDH1A1KDM4EGAAHPGD
SCHEMBL14037032 0.82 ALDH1A1 (0.64) LMNAALDH1A1KDM4EGAAHPGD
SCHEMBL7378146 0.81 LMNA (0.51) LMNAALDH1A1KDM4EGAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10590208-B2 Polymers functionalized with imine compounds containing a cyano group BRIDGESTONE CORPORATION (JP) 2020-03-17 US claimed
EP-3052531-B1 POLYMERS FUNCTIONALIZED WITH IMINE COMPOUNDS CONTAINING A CYANO GROUP BRIDGESTONE CORP (JP) 2024-07-24 EP disclosed
US-11066486-B2 Polymers functionalized with imine compounds containing a cyano group BRIDGESTONE CORPORATION (JP) 2021-07-20 US disclosed
US-20200157253-A1 POLYMERS FUNCTIONALIZED WITH IMINE COMPOUNDS CONTAINING A CYANO GROUP BRIDGESTONE CORPORATION (JP) 2020-05-21 US disclosed
US-10590208-B2 Polymers functionalized with imine compounds containing a cyano group BRIDGESTONE CORPORATION (JP) 2020-03-17 US disclosed
US-20160237179-A1 Polymers Functionalized With Imine Compounds Containing A Cyano Group BRIDGESTONE CORPORATION (JP) 2016-08-18 US disclosed
EP-3052531-A1 POLYMERS FUNCTIONALIZED WITH IMINE COMPOUNDS CONTAINING A CYANO GROUP Bridgestone Corporation (JP) 2016-08-10 EP disclosed
WO-2015050947-A1 POLYMERS FUNCTIONALIZED WITH IMINE COMPOUNDS CONTAINING A CYANO GROUP BRIDGESTONE CORPORATION (JP) 2015-04-09 WO disclosed