Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 5/20 | 0.39 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.39 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.38 |
| ▸ | GGH | Q92820 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL1663212 | 1.00 | FOLH1 (0.39) | FOLH1NAALAD2C3AR1GGHSLC1A2 | |
| Arginine SCHEMBL1660453 | 1.00 | FOLH1 (0.39) | FOLH1NAALAD2C3AR1GGHSLC1A2 | |
| Arginine SCHEMBL12002430 | 1.00 | FOLH1 (0.39) | FOLH1NAALAD2C3AR1GGHSLC1A2 | |
| SCHEMBL1660547 | 0.88 | C3AR1 (0.46) | FOLH1C3AR1 | |
| SCHEMBL1660342 | 0.88 | C3AR1 (0.46) | FOLH1C3AR1 | |
| SCHEMBL12002454 | 0.82 | NAALAD2 (0.54) | FOLH1NAALAD2GGHGAAMMP9 | |
| SCHEMBL1663305 | 0.82 | NAALAD2 (0.54) | FOLH1NAALAD2GGHGAAMMP9 | |
| SCHEMBL21722104 | 0.79 | C3AR1 (0.46) | C3AR1 | |
| Arginine SCHEMBL15676629 | 0.79 | GRM8 (0.46) | FOLH1NAALAD2SLC1A2SLC1A1GRM8 | |
| Arginine SCHEMBL5706216 | 0.77 | GSR (0.47) | SLC1A2SLC1A1GRM8GRM6GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491051-A2 | GADD45BETA TARGETING AGENTS | Imperial Innovations Limited (GB) | 2012-08-29 | — | — | EP | claimed |
| WO-2011048390-A2 | GADD45BETA TARGETING AGENTS | IMPERIAL INNOVATIONS LIMITED (GB) | 2011-04-28 | — | — | WO | claimed |