Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25886583 | 0.79 | POLB (0.31) | POLBMAPK14FGFR2FGFR3 | |
| SCHEMBL20936363 | 0.79 | POLB (0.31) | KDM4EALDH1A1SMN1; SMN2POLBMAPK14 | |
| SCHEMBL30989615 | 0.79 | POLB (0.31) | POLBMAPK14FGFR2FGFR3 | |
| SCHEMBL15412441 | 0.76 | ALOX5AP (0.35) | KDM4ENPC1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL10281005 | 0.76 | ALOX5AP (0.43) | KDM4ENPC1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL20708672 | 0.74 | DDR1 (0.37) | KDM4ENPC1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL16611998 | 0.74 | POLB (0.53) | POLBMAPK14KMT2AAGBL2 | |
| SCHEMBL20708642 | 0.72 | POLB (0.30) | POLB | |
| SCHEMBL20936362 | 0.71 | LMNA (0.31) | — | |
| SCHEMBL14347230 | 0.70 | PDE2A (0.39) | KDM4ESMN1; SMN2POLBCCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2857397-A1 | FUSED HETEROCYCLIC COMPOUND | Sumitomo Chemical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |