Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 2/20 | 0.30 |
| ▸ | PDXK | O00764 | 1/20 | 0.30 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL335743 | 0.79 | SRC (0.35) | PTGS1PTGS2AGBL2 | |
| SCHEMBL35528 | 0.78 | PDXK (0.39) | TP53TDP1PARP1HDAC8GRM5 | |
| SCHEMBL29419055 | 0.78 | PDXK (0.39) | TP53TDP1PARP1HDAC8GRM5 | |
| SCHEMBL20083747 | 0.75 | PIK3CA (0.34) | TP53TDP1PARP1HDAC8 | |
| SCHEMBL30938635 | 0.75 | TDP1 (0.33) | TP53TDP1PARP1HDAC8GRM5 | |
| SCHEMBL115734 | 0.75 | PARP1 (0.33) | PARP1 | |
| SCHEMBL26654238 | 0.75 | NPC1 (0.40) | — | |
| SCHEMBL29953419 | 0.75 | PARP1 (0.33) | PARP1 | |
| SCHEMBL29769000 | 0.72 | TRPA1 (0.34) | TP53TDP1PARP1 | |
| SCHEMBL19021560 | 0.71 | PDGFRB (0.34) | PARP1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | disclosed |