Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ULK1 | O75385 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16623467 | 1.00 | HPGD (0.32) | HPGDHTTULK1POLBTDP1 | |
| SCHEMBL16726703 | 1.00 | HPGD (0.32) | HPGDHTTULK1POLBTDP1 | |
| SCHEMBL16726671 | 0.95 | HPGD (0.34) | HPGDHTT | |
| SCHEMBL16726667 | 0.80 | HPGD (0.31) | HPGDHTT | |
| SCHEMBL16623541 | 0.76 | EGFR (0.34) | HPGDHTT | |
| SCHEMBL16623523 | 0.76 | HPGD (0.33) | HPGDHTT | |
| SCHEMBL16623551 | 0.75 | JAK1 (0.34) | — | |
| SCHEMBL16726647 | 0.74 | — | — | |
| SCHEMBL16623491 | 0.74 | JAK1 (0.34) | — | |
| SCHEMBL16623536 | 0.74 | HSP90AA1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| US-9371320-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-21 | — | — | US | disclosed |
| EP-2857400-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |