Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.60 |
| ▸ | TSHR | P16473 | 6/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16626213 | 0.91 | EGLN1 (0.52) | ALDH1A1CLK4TSHRMAPK1CYP2C19 | |
| SCHEMBL16626264 | 0.88 | EGLN1 (0.68) | ALDH1A1EGLN1LMNAHTTKDM4E | |
| SCHEMBL14992162 | 0.85 | ALDH1A1 (0.47) | ALDH1A1CLK4TSHRMAPK1CYP2C19 | |
| SCHEMBL14992529 | 0.85 | EGLN1 (0.49) | ALDH1A1CLK4TSHRMAPK1CYP2C19 | |
| SCHEMBL622122 | 0.83 | EGLN1 (0.79) | EGLN1 | |
| SCHEMBL16626164 | 0.82 | EGLN1 (0.66) | ALDH1A1EGLN1LMNAHTTKDM4E | |
| SCHEMBL4879139 | 0.80 | ALDH1A1 (0.69) | ALDH1A1CLK4TSHRMAPK1CYP2C19 | |
| SCHEMBL16626232 | 0.79 | EGLN1 (0.68) | ALDH1A1EGLN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27919419 | 0.79 | LMNA (0.44) | ALDH1A1CLK4TSHRMAPK1CYP2C19 | |
| SCHEMBL16626176 | 0.78 | EGLN1 (0.66) | TSHRMAPK1EGLN1HTTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975062-B2 | 4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors | JANSSEN PHARMACEUTICA NV | 2021-04-13 | — | — | US | disclosed |
| US-20200095234-A1 | 4-AMINOQUINAZOLINYL COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-03-26 | — | — | US | disclosed |
| US-9006251-B2 | 4-aminoquinazolin-2-yl-1-pyrrazole-4-carboxylic acid compounds as prolyl hydroxylase inhibitors | JANSSEN PHARAMCEUTICA NV (BE) | 2015-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10975062-B2 | 4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors | P4HA1, EGLN3, EGLN2 | ALDH1A1 132/4885CLK4 3633/4885TSHR 4300/4885 |
| US-20200095234-A1 | 4-AMINOQUINAZOLINYL COMPOUNDS AS PROLYL HYDROXYLASE INHIBITORS | P4HA1, EGLN3, EGLN2 | ALDH1A1 132/4885CLK4 3633/4885TSHR 4300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.