Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 9/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.60 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.58 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.58 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.54 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.54 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1169201 | 0.87 | L3MBTL3 (0.60) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| Hydrochloric Acid SCHEMBL1169797 | 0.86 | L3MBTL3 (0.59) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL1169247 | 0.84 | HRH3 (0.66) | L3MBTL3L3MBTL1HRH3SLC6A4 | |
| SCHEMBL911564 | 0.82 | MGLL (0.67) | L3MBTL3L3MBTL1ALDH1A1KDM4EPOLB | |
| SCHEMBL1376624 | 0.81 | PDK1 (0.59) | L3MBTL1ALDH1A1PDK1PDK2PDK3 | |
| SCHEMBL599473 | 0.80 | HRH3 (0.59) | L3MBTL3L3MBTL1HRH3SLC6A4ALDH1A1 | |
| SCHEMBL31387924 | 0.80 | HPGD (0.68) | L3MBTL1ALDH1A1PDK1PDK2PDK3 | |
| SCHEMBL31387922 | 0.80 | HPGD (0.68) | L3MBTL1ALDH1A1PDK1PDK2PDK3 | |
| SCHEMBL13503971 | 0.80 | GRM5 (0.69) | L3MBTL3ALDH1A1PDK1PDK2PDK3 | |
| SCHEMBL10215017 | 0.80 | KDM1A (0.66) | ALDH1A1PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822656-B1 | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE | CANCER RES INST ROYAL (GB) | 2016-10-19 | — | — | EP | disclosed |
| US-9193689-B2 | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use | INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) | 2015-11-24 | — | — | US | disclosed |
| US-20150099732-A1 | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE | INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) | 2015-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099732-A1 | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE | TNKS, TNKS2, PARP11 | L3MBTL3 1815/4885L3MBTL1 1629/4885MBTD1 2608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.