Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16627793 | 0.94 | P2RX7 (0.80) | P2RX7HDAC1P2RX4MAPK8PDE1B | |
| SCHEMBL16627901 | 0.90 | P2RX7 (0.78) | P2RX7HDAC1P2RX4MAPK8MAPT | |
| SCHEMBL16627903 | 0.84 | P2RX7 (0.81) | P2RX7HDAC1P2RX4MAPTTP53 | |
| SCHEMBL16627629 | 0.81 | P2RX7 (0.60) | P2RX7HDAC1P2RX4PDE1BPDE1C | |
| SCHEMBL16627902 | 0.80 | P2RX7 (1.00) | P2RX7HDAC1P2RX4TP53NPC1 | |
| SCHEMBL16627866 | 0.78 | P2RX7 (0.49) | P2RX7HDAC1P2RX4MAPK8HDAC11 | |
| SCHEMBL16627612 | 0.78 | P2RX7 (1.00) | P2RX7P2RX4LMNA | |
| SCHEMBL16627791 | 0.77 | P2RX7 (0.69) | P2RX7HDAC1P2RX4MAPK8MAPT | |
| SCHEMBL16627607 | 0.77 | P2RX7 (0.79) | P2RX7MAPK8MAPTTP53RXFP1 | |
| SCHEMBL16627907 | 0.76 | P2RX7 (0.79) | P2RX7HDAC1P2RX4MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015050379-A1 | NOVEL QUINOLINONE DERIVATIVE AND USE THEREOF | 광주과학기술원 | 2015-04-09 | — | — | WO | disclosed |