Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16621119 | 0.81 | ALDH1A1 (0.47) | DHFRP2RX7MEN1KMT2ASCN9A | |
| SCHEMBL16628134 | 0.81 | KCNA3 (0.47) | P2RX7EPHX2MEN1KMT2AKCNA3 | |
| SCHEMBL1283337 | 0.81 | SCN9A (0.39) | DHFREPHX2MEN1KMT2ACNR2 | |
| SCHEMBL30594741 | 0.80 | DHFR (0.49) | DHFRSCN9A | |
| SCHEMBL420844 | 0.80 | MEN1 (0.48) | P2RX7EPHX2MEN1KMT2AFAAH | |
| SCHEMBL2957472 | 0.79 | ALDH1A1 (0.44) | DHFREPHX2MEN1KMT2ASCN9A | |
| Hydrochloric Acid SCHEMBL9453210 | 0.79 | MEN1 (0.47) | P2RX7EPHX2MEN1KMT2AFAAH | |
| SCHEMBL4058195 | 0.78 | ALDH1A1 (0.41) | DHFRMEN1KMT2ASCN9A | |
| SCHEMBL2748151 | 0.76 | MEN1 (0.47) | EPHX2MEN1KMT2A | |
| SCHEMBL9622664 | 0.76 | SRD5A2 (0.49) | EPHX2MEN1KMT2AFAAHCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |