SCHEMBL16628147

SCHEMBL16628147

CCOC(=O)c1ccc(Oc2ccc(N)cc2)cc1

nearest known ligand 0.83

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.83
CYP1A2 P05177 2/20 0.83
CYP3A4 P08684 2/20 0.83
MAOA P21397 2/20 0.83
TSHR P16473 3/20 0.63
CYP2C9 P11712 1/20 0.63
CYP2C19 P33261 1/20 0.63
PDE4D Q08499 1/20 0.63
STS P08842 1/20 0.59
CA1 P00915 2/20 0.58
CA2 P00918 2/20 0.58
PARP10 Q53GL7 1/20 0.58
CA12 O43570 1/20 0.58
ESR1 P03372 1/20 0.58
CA7 P43166 1/20 0.58
CA9 Q16790 1/20 0.58
ESR2 Q92731 1/20 0.58
CA14 Q9ULX7 1/20 0.58
ALDH1A1 P00352 2/20 0.55
NPC1 O15118 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8656770 0.91 CA12 (0.68) LMNACYP1A2CYP3A4MAOATSHR
Benzocaine SCHEMBL1235972 0.91 LMNA (1.00) LMNACYP1A2CYP3A4MAOATSHR
Benzocaine SCHEMBL25100 0.91 LMNA (1.00) LMNACYP1A2CYP3A4MAOATSHR
Benzocaine SCHEMBL19031788 0.89 LMNA (0.96) LMNACYP1A2CYP3A4MAOATSHR
Benzocaine SCHEMBL27914401 0.89 LMNA (0.96) LMNACYP1A2CYP3A4MAOATSHR
Benzocaine SCHEMBL944986 0.89 LMNA (0.96) LMNACYP1A2CYP3A4MAOATSHR
Benzocaine SCHEMBL11021778 0.89 LMNA (0.96) LMNACYP1A2CYP3A4MAOATSHR
Benzocaine SCHEMBL15200678 0.89 LMNA (0.96) LMNACYP1A2CYP3A4MAOATSHR
Benzocaine SCHEMBL29029466 0.87 LMNA (0.92) LMNACYP1A2CYP3A4MAOATSHR
Benzocaine SCHEMBL2389408 0.87 LMNA (0.92) LMNACYP1A2CYP3A4MAOATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015051149-A1 SORAFENIB ANALOGS AND USES THEREOF THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2015-04-09 WO disclosed