Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | PDE6D | O43924 | 2/20 | 0.41 |
| ▸ | PDE6A | P16499 | 2/20 | 0.41 |
| ▸ | PDE6G | P18545 | 2/20 | 0.41 |
| ▸ | PDE6B | P35913 | 2/20 | 0.41 |
| ▸ | PDE6C | P51160 | 2/20 | 0.41 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22001178 | 0.82 | POLB (0.39) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16593586 | 0.80 | TLR7 (0.38) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL16628260 | 0.80 | CHRM1 (0.46) | ADRA1DPDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16628326 | 0.79 | PDE6D (0.41) | ADRA1DPDE6DPDE6APDE6GPDE6B | |
| SCHEMBL21042577 | 0.78 | CHRM1 (0.67) | CHRM1 | |
| SCHEMBL16593344 | 0.78 | CHRM1 (0.67) | CHRM1 | |
| SCHEMBL19997523 | 0.78 | CHRM1 (0.48) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL30437365 | 0.78 | KDM4E (0.48) | PDE6DPDE6APDE6GPDE6BPDE6C | |
| SCHEMBL18011014 | 0.76 | CHRM1 (0.43) | ADRA1DPDE6DPDE6APDE6GPDE6B | |
| SCHEMBL16628259 | 0.75 | ADRA1D (0.50) | ADRA1DKDM4EMAPTRAB9ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-A1 | 4-AZAINDOLE DERIVATIVES | Eisai R&D Management Co., Ltd. (JP) | 2019-05-29 | — | — | EP | disclosed |
| WO-2015049574-A1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-04-09 | — | — | WO | disclosed |