SCHEMBL16628854

SCHEMBL16628854

Fc1cccc(-c2ccc(-c3ccccc3)c(F)c2F)c1F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.43
FEN1 P39748 1/20 0.43
WDR5 P61964 1/20 0.42
MAPK1 P28482 2/20 0.42
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
PKM P14618 1/20 0.42
NFKB1 P19838 1/20 0.42
RAB9A P51151 1/20 0.42
NFKB2 Q00653 1/20 0.42
KMT2A Q03164 1/20 0.42
RELA Q04206 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
GRM5 P41594 1/20 0.40
HTT P42858 1/20 0.39
DHODH Q02127 1/20 0.38
ALDH1A1 P00352 3/20 0.38
HSD17B10 Q99714 2/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19400468 0.96 WDR5 (0.43) ALOX5APFEN1WDR5MAPK1MEN1
SCHEMBL200742 0.93 ALDH1A1 (0.42) ALOX5APFEN1WDR5MAPK1MEN1
Methane SCHEMBL28995944 0.91 ALDH1A1 (0.41) ALOX5APFEN1WDR5MAPK1MEN1
SCHEMBL27346716 0.91 ALDH1A1 (0.41) ALOX5APFEN1WDR5MAPK1MEN1
SCHEMBL17889182 0.89 MAPK1 (0.43) WDR5MAPK1MEN1NPC1PKM
Hydrochloric Acid SCHEMBL9010527 0.89 WDR5 (0.40) ALOX5APFEN1WDR5MAPK1MEN1
SCHEMBL8124727 0.89 WDR5 (0.43) WDR5MAPK1MEN1NPC1PKM
Ethane SCHEMBL27611886 0.89 HDAC3 (0.41) WDR5MAPK1MEN1NPC1PKM
Cyanide SCHEMBL28270938 0.87 HSD11B1 (0.39) ALOX5APFEN1WDR5MAPK1MEN1
Chloromethane SCHEMBL27523745 0.87 CYP2A6 (0.43) WDR5MAPK1MEN1NPC1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022128845-A1 HETEROAROMATIC ISOTHIOCYANATES MERCK PATENT GMBH (DE) 2022-06-23 WO disclosed
EP-2860236-A1 LIQUID-CRYSTAL COMPOSITION DIC Corporation (JP) 2015-04-15 EP disclosed