Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2261759 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2TP53RIPK1ADORA3KMT2A | |
| SCHEMBL22892041 | 0.96 | TP53 (0.52) | SMN1; SMN2TP53RIPK1KMT2AMEN1 | |
| SCHEMBL13365619 | 0.77 | MAPT (0.54) | SMN1; SMN2TP53ADORA3NPC1RAB9A | |
| SCHEMBL3109357 | 0.71 | SMN1; SMN2 (0.65) | SMN1; SMN2TP53KMT2AMEN1NPC1 | |
| SCHEMBL3068648 | 0.70 | P2RX3 (0.50) | — | |
| SCHEMBL2259547 | 0.70 | ADORA3 (0.56) | SMN1; SMN2ADORA3KMT2AMEN1ADORA1 | |
| SCHEMBL17582100 | 0.70 | RIPK1 (0.50) | SMN1; SMN2TP53RIPK1KMT2AMEN1 | |
| SCHEMBL452633 | 0.70 | RIPK1 (0.50) | SMN1; SMN2TP53RIPK1KMT2AMEN1 | |
| SCHEMBL2259750 | 0.69 | ADORA3 (0.56) | SMN1; SMN2TP53ADORA3KMT2AMEN1 | |
| SCHEMBL1072108 | 0.68 | P2RX3 (0.47) | SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2860178-A2 | P2X3 receptor antagonists for treatment of pain | Merck Sharp & Dohme Corp. (US) | 2015-04-15 | — | — | EP | disclosed |