Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 3/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 5/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067290 | 0.89 | CDK4 (0.41) | CDK4CCND1PTGESJAK2PARP1 | |
| SCHEMBL16624849 | 0.88 | PTGES (0.41) | GSK3AGSK3BCDK4CCND1PTGES | |
| SCHEMBL10067287 | 0.88 | KIF11 (0.45) | GSK3AGSK3BCDK5CDK4CCND1 | |
| SCHEMBL10067297 | 0.87 | PTGES (0.37) | GSK3AGSK3BCDK5CDK5R1CDK4 | |
| SCHEMBL10067328 | 0.87 | PTGES (0.43) | GSK3AGSK3BCDK5CDK5R1CDK4 | |
| SCHEMBL10067315 | 0.86 | PTGES (0.40) | CDK4CCND1PTGESJAK2GABRA1 | |
| SCHEMBL16629721 | 0.85 | KDM4E (0.43) | GSK3AGSK3BCDK5CDK5R1CDK4 | |
| SCHEMBL10067285 | 0.85 | PTGES (0.41) | CDK4CCND1PTGESKDM4EMAPT | |
| SCHEMBL10067300 | 0.84 | CDK4 (0.33) | CDK4CCND1PTGESJAK2PARP1 | |
| SCHEMBL10082768 | 0.84 | L3MBTL1 (0.41) | GSK3AGSK3BCDK5CDK5R1CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051302-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCERS | APTOSE BIOSCIENCES INC. (CA) | 2015-04-09 | — | — | WO | disclosed |