Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.37 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16630788 | 0.84 | MAPK1 (0.36) | MAPK1PIK3C3ALDH1A1IRAK4GRM5 | |
| SCHEMBL16619911 | 0.83 | FTO (0.40) | KDM4CFTORORCMAPK1SORT1 | |
| SCHEMBL19223209 | 0.80 | MAPK1 (0.55) | MAPK1 | |
| SCHEMBL15294473 | 0.77 | HPGD (0.42) | KDM4CFTOKDM4EMAPK1ALDH1A1 | |
| SCHEMBL19223243 | 0.72 | NPC1 (0.41) | FTOMAPK1ALDH1A1 | |
| SCHEMBL15248449 | 0.72 | ALDH1A1 (0.46) | KDM4CKDM4EMAPK1ALDH1A1 | |
| SCHEMBL15248177 | 0.71 | MAPK1 (0.43) | MAPK1 | |
| SCHEMBL16619783 | 0.71 | MAPK1 (0.37) | FTORORCKDM4EMAPK1ALDH1A1 | |
| SCHEMBL16620394 | 0.70 | MAPK1 (0.35) | MAPK1 | |
| SCHEMBL18022541 | 0.70 | FTO (0.40) | KDM4CFTOKDM4EHSD17B10SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051341-A1 | INHIBITORS OF ERK AND METHODS OF USE | ARAXES PHARMA LLC (US) | 2015-04-09 | — | — | WO | disclosed |