⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9174410 | 0.80 | — | — | |
| SCHEMBL2510884 | 0.76 | TSHR (0.39) | — | |
| SCHEMBL2076291 | 0.76 | TDP1 (0.33) | — | |
| SCHEMBL8734845 | 0.74 | — | — | |
| SCHEMBL6586426 | 0.74 | CETP (0.31) | — | |
| SCHEMBL7705963 | 0.74 | — | — | |
| SCHEMBL7810060 | 0.72 | THRB (0.32) | — | |
| SCHEMBL15285469 | 0.69 | — | — | |
| SCHEMBL17491821 | 0.67 | — | — | |
| SCHEMBL16460151 | 0.67 | CPB2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9487533-B2 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2016-11-08 | — | — | US | disclosed |
| EP-2114950-B1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2016-03-09 | — | — | EP | disclosed |
| US-20120270769-A1 | METHODS OF USING MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES | TRANZYME PHARMA INC. (CA) | 2012-10-25 | — | — | US | disclosed |
| US-20120270807-A1 | MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES | TRANZYME PHARMA INC. (CA) | 2012-10-25 | — | — | US | disclosed |
| EP-2491020-A1 | METHODS OF USING MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES | Tranzyme Pharma, Inc. (US) | 2012-08-29 | — | — | EP | disclosed |
| EP-2491004-A2 | MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES | Tranzyme Pharma, Inc. (US) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011050270-A2 | MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES | TRANZYME PHARMA, INC. (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011050276-A1 | METHODS OF USING MACROCYCLIC INHIBITORS OF SERINE PROTEASE ENZYMES | TRANZYME PHARMA, INC. (US) | 2011-04-28 | — | — | WO | disclosed |
| EP-2114950-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| US-20080269210-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-30 | — | — | US | disclosed |
| WO-2008073785-A2 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| EP-1208234-A1 | POLY(ETHER-THIOETHER), POLY(ETHER-SULFOXIDE) AND POLY(ETHER-SULFONE) NUCLEIC ACIDS | BIO-RAD LABORATORIES, INC. (US) | 2002-05-29 | — | — | EP | disclosed |
| US-6348583-B1 | NUCLEOBASE CONTAINING POLYTHIOETHERS SYNTHESIZED ON POLYETHYLENE GLYCOL, SUCCINIC ANHYDRIDE AND PROPYLAMINE MODIFIED GLASS; NUCLEIC ACID MIMETICS | BIO-RAD LABORATORIES, INC. | 2002-02-19 | — | — | US | disclosed |
| WO-2001016365-A1 | POLY(ETHER-THIOETHER), POLY(ETHER-SULFOXIDE) AND POLY(ETHER-SULFONE) NUCLEIC ACIDS | BIO-RAD LABORATORIES, INC. (US) | 2001-03-08 | — | — | WO | disclosed |
| US-5214139-A | 2-phenanthridonyl-carbapenems | MERCK & CO., INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5208328-A | Intermediates for antibiotics and bactericides | MERCK & CO., INC. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0509780-A1 | 2-phenanthridonyl carbapenems | MERCK & CO. INC. (US) | 1992-10-21 | — | — | EP | disclosed |
| EP-0509756-A1 | 2-Phenanthridonyl carbapenems having cationizeable substituents | MERCK & CO. INC. (US) | 1992-10-21 | — | — | EP | disclosed |
| US-5157033-A | Controlling methicillin-resistant grampositive Staphylococcus; bactericides | MERCK & CO., INC. (US) | 1992-10-20 | — | — | US | disclosed |
| US-5153185-A | Antibiotics for methicillin resistant Staphylococcus strains | MERCK & CO., INC. (US) | 1992-10-06 | — | — | US | disclosed |