Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662797 | 0.85 | — | — | |
| SCHEMBL1662613 | 0.82 | ALDH1A1 (0.34) | BRAFALDH1A1SMN1; SMN2 | |
| SCHEMBL1665283 | 0.79 | GPR119 (0.48) | HTTALDH1A1 | |
| SCHEMBL671776 | 0.77 | ALDH1A1 (0.42) | HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL671924 | 0.71 | AOC3 (0.38) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL28296311 | 0.68 | PHGDH (0.40) | HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL16429868 | 0.68 | ALDH1A1 (0.46) | HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL27250548 | 0.68 | ALDH1A1 (0.37) | HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL12631516 | 0.67 | ALDH1A1 (0.46) | HTTALDH1A1SMN1; SMN2 | |
| SCHEMBL358960 | 0.67 | CA1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491039-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | Cellzome Limited (GB) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |