SCHEMBL16631297

SCHEMBL16631297

CO[C@H]1C(O)[C@@H](CO)O[C@H]1c1cnc(=O)[nH]c1

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 3/20 0.39
PNP P00491 2/20 0.36
TNF P01375 1/20 0.35
IL6 P05231 1/20 0.35
OGA O60502 1/20 0.35
LGALS8 O00214 4/20 0.35
LMNA P02545 1/20 0.35
TSHR P16473 1/20 0.35
LGALS3 P17931 1/20 0.34
PYGL P06737 2/20 0.34
MAPT P10636 1/20 0.34
CDA P32320 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16631479 0.84 SLC5A2 (0.45) SLC5A2PNPPYGLMAPTCDA
SCHEMBL16631521 0.81 CDA (0.38) SLC5A2PNPOGAPYGLMAPT
SCHEMBL18079914 0.80 SLC5A2 (0.44) SLC5A2LGALS8LGALS3
SCHEMBL18079985 0.79 P2RX3 (0.45)
SCHEMBL18079915 0.78 SLC5A2 (0.41) SLC5A2TNFIL6LGALS8LMNA
SCHEMBL16631435 0.78 PNP (0.35) SLC5A2PNPTNFIL6OGA
SCHEMBL16631380 0.77 PYGL (0.36) SLC5A2PNPTNFIL6OGA
SCHEMBL16631377 0.76 PNP (0.36) SLC5A2PNPTNFIL6OGA
SCHEMBL16631505 0.75 PYGL (0.33) SLC5A2PNPTNFIL6OGA
SCHEMBL16631528 0.74 PYGL (0.34) SLC5A2PNPTNFIL6OGA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160264614-A1 POLYNUCLEOTIDE MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2016-09-15 US disclosed
US-20160264614-A1 POLYNUCLEOTIDE MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2016-09-15 US disclosed
WO-2015051173-A2 POLYNUCLEOTIDE MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC (US) 2015-04-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160264614-A1 POLYNUCLEOTIDE MOLECULES AND USES THEREOF POLRMT, POLN, NSUN3 SLC5A2 3235/4885PNP 7/4885TNF 4770/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.