Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 6/20 | 0.38 |
| ▸ | CA12 | O43570 | 5/20 | 0.38 |
| ▸ | CA1 | P00915 | 5/20 | 0.38 |
| ▸ | CA2 | P00918 | 5/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 4/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18081899 | 0.85 | CA9 (0.35) | CA9CA12CA1CA2AMY1A | |
| SCHEMBL18080383 | 0.82 | CA12 (0.34) | CA9CA12CA1CA2AMY1A | |
| SCHEMBL16631483 | 0.80 | EGLN2 (0.40) | CA9CA12CA1CA2SMN1; SMN2 | |
| SCHEMBL23957853 | 0.70 | MAPK1 (0.43) | SMN1; SMN2GRIN1GRIN2BPDE4AADORA2A | |
| SCHEMBL16631677 | 0.69 | MAPK1 (0.44) | — | |
| SCHEMBL16631388 | 0.68 | KCNMA1 (0.47) | — | |
| SCHEMBL2183944 | 0.67 | MAPK1 (0.61) | SMN1; SMN2 | |
| SCHEMBL18080384 | 0.66 | KCNMA1 (0.46) | — | |
| SCHEMBL3274999 | 0.66 | SMN1; SMN2 (0.40) | SMN1; SMN2PDE4AADORA2APDE4BPDE4C | |
| SCHEMBL18080418 | 0.66 | EP300 (0.33) | CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051173-A2 | POLYNUCLEOTIDE MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC (US) | 2015-04-09 | — | — | WO | disclosed |