Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.31 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.31 |
| ▸ | TYMP | P19971 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18081752 | 0.83 | EGLN2 (0.39) | EGLN2HTTNOTUM | |
| SCHEMBL18080381 | 0.82 | EGLN2 (0.38) | EGLN2 | |
| SCHEMBL16631319 | 0.80 | CA9 (0.38) | SMN1; SMN2PDE4AADORA2APDE4BPDE4C | |
| SCHEMBL16631423 | 0.71 | PYGM (0.55) | — | |
| SCHEMBL13384443 | 0.71 | SMN1; SMN2 (0.40) | SMN1; SMN2HTTPDE4AADORA2APDE4B | |
| SCHEMBL16631711 | 0.70 | TK1 (0.33) | EGLN2HTTMAPK1 | |
| SCHEMBL18081935 | 0.69 | MAPK1 (0.43) | TYMPMAPK1 | |
| SCHEMBL18080420 | 0.69 | TYMP (0.32) | EGLN2HTTTYMP | |
| SCHEMBL18080383 | 0.69 | CA12 (0.34) | SMN1; SMN2CA12CA1CA2CA9 | |
| SCHEMBL18081899 | 0.66 | CA9 (0.35) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051173-A2 | POLYNUCLEOTIDE MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC (US) | 2015-04-09 | — | — | WO | disclosed |