Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18165301 | 0.91 | AKR1B1 (0.47) | ROCK2AKR1B1MAOAMAOBLTB4R | |
| SCHEMBL16631357 | 0.82 | ROCK2 (0.41) | ROCK2AKR1B1MAOA | |
| SCHEMBL16631400 | 0.76 | ROCK2 (0.40) | ROCK2AKR1B1ROCK1 | |
| SCHEMBL17954207 | 0.74 | PRF1 (0.37) | ROCK2AKR1B1ROCK1 | |
| SCHEMBL18165307 | 0.74 | AKR1B1 (0.47) | ROCK2AKR1B1LTB4RLTB4R2 | |
| SCHEMBL10898501 | 0.73 | HTR2C (0.54) | ALDH1A1MAOA | |
| SCHEMBL18165309 | 0.72 | FFAR1 (0.51) | AKR1B1MAOAMAOB | |
| SCHEMBL20216036 | 0.71 | ROCK2 (0.38) | ROCK2AKR1B1ROCK1 | |
| SCHEMBL22540441 | 0.71 | FFAR1 (0.49) | AKR1B1MAOAMAOB | |
| SCHEMBL5657672 | 0.71 | AKR1B1 (0.58) | ROCK2AKR1B1LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051045-A2 | 3'END CAPS FOR RNAi AGENTS FOR USE IN RNA INTERFERENCE | NOVARTIS AG (CH) | 2015-04-09 | — | — | WO | disclosed |