Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 9/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16631512 | 0.93 | AKR1B1 (0.41) | ROCK2AKR1B1FAAHMGLLAAK1 | |
| SCHEMBL16624806 | 0.83 | ROCK2 (0.38) | ROCK2AKR1B1MAPTPOLBROCK1 | |
| SCHEMBL17954207 | 0.82 | PRF1 (0.37) | ROCK2AKR1B1MAPTTP53POLB | |
| SCHEMBL18165301 | 0.79 | AKR1B1 (0.47) | ROCK2AKR1B1 | |
| SCHEMBL16627087 | 0.78 | ROCK2 (0.35) | ROCK2AAK1MAPTPOLBROCK1 | |
| SCHEMBL16624802 | 0.76 | ROCK2 (0.41) | ROCK2AKR1B1FAAHMGLLAAK1 | |
| SCHEMBL16631329 | 0.76 | ROCK2 (0.44) | ROCK2AKR1B1ROCK1 | |
| SCHEMBL16624619 | 0.75 | MAOA (0.41) | ROCK2TP53ROCK1 | |
| SCHEMBL9980133 | 0.73 | PARP1 (0.44) | ROCK2AKR1B1AAK1MAPTPOLB | |
| SCHEMBL17954215 | 0.72 | MAOB (0.48) | ROCK2MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051045-A2 | 3'END CAPS FOR RNAi AGENTS FOR USE IN RNA INTERFERENCE | NOVARTIS AG (CH) | 2015-04-09 | — | — | WO | disclosed |