SCHEMBL16631579

SCHEMBL16631579

Cc1cc([C@@H]2O[C@H](CO)C(O)[C@@H]2F)c(F)[nH]c1=O

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SLC5A2 P31639 10/20 0.37
CDA P32320 1/20 0.37
SLC5A1 P13866 2/20 0.35
SYNJ2 O15056 1/20 0.34
TNF P01375 1/20 0.34
IL6 P05231 1/20 0.34
PNP P00491 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16631248 0.90 SLC5A2 (0.43) SLC5A2SLC5A1SYNJ2
SCHEMBL16631254 0.89 SLC5A2 (0.38) SLC5A2CDASLC5A1SYNJ2TNF
SCHEMBL16631354 0.84 TK2 (0.37) SLC5A2TNFIL6PNP
SCHEMBL16631167 0.83 SLC5A2 (0.35) SLC5A2CDASLC5A1SYNJ2TNF
SCHEMBL16631839 0.82 SLC5A2 (0.35) SLC5A2CDASLC5A1SYNJ2TNF
SCHEMBL16631503 0.79 PYGL (0.38) SLC5A2CDAPNP
SCHEMBL16631525 0.78 SLC28A1 (0.41) SLC5A2CDAPNP
SCHEMBL16631250 0.76 SLC5A2 (0.44) SLC5A2SLC5A1SYNJ2
SCHEMBL16631547 0.76 SLC5A2 (0.42) SLC5A2CDASYNJ2TNFIL6
SCHEMBL16631160 0.76 CDA (0.35) CDASYNJ2TNFIL6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160264614-A1 POLYNUCLEOTIDE MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2016-09-15 US disclosed
US-20160264614-A1 POLYNUCLEOTIDE MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2016-09-15 US disclosed
WO-2015051173-A2 POLYNUCLEOTIDE MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC (US) 2015-04-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160264614-A1 POLYNUCLEOTIDE MOLECULES AND USES THEREOF POLRMT, POLN, NSUN3 SLC5A2 3235/4885CDA 200/4885SLC5A1 3466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.