Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18081975 | 0.83 | ALDH1A1 (0.45) | KDM4EALDH1A1GAASMN1; SMN2TP53 | |
| SCHEMBL18080556 | 0.77 | KDM4E (0.40) | KDM4EALDH1A1GAASMN1; SMN2TP53 | |
| SCHEMBL16631923 | 0.74 | ALDH1A1 (0.42) | KDM4EALDH1A1GAASMN1; SMN2TP53 | |
| SCHEMBL16631749 | 0.73 | HTT (0.33) | HTTKDM5B | |
| SCHEMBL16631920 | 0.70 | CRBN (0.34) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL18080560 | 0.69 | ALDH1A1 (0.38) | KDM4EALDH1A1GAASMN1; SMN2TP53 | |
| SCHEMBL15107929 | 0.61 | SMN1; SMN2 (0.69) | ALDH1A1SMN1; SMN2LMNACYP1A2POLB | |
| SCHEMBL18080557 | 0.61 | CHEK1 (0.33) | PDE2A | |
| SCHEMBL16631750 | 0.61 | HTT (0.33) | KDM4EALDH1A1HTTHPGDKDM5B | |
| SCHEMBL24378545 | 0.60 | GAA (0.47) | KDM4EALDH1A1GAARAB9ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051173-A2 | POLYNUCLEOTIDE MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC (US) | 2015-04-09 | — | — | WO | disclosed |