Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16631936 | 0.83 | HIF1A (0.33) | KDM4EMAPTSMPD3ALDH1A1LMNA | |
| SCHEMBL18081816 | 0.80 | KDM4E (0.41) | KDM4EKMT2AOPRK1MAPTSMPD3 | |
| SCHEMBL16631938 | 0.76 | KMT2A (0.36) | KDM4EKMT2AOPRK1MAPTRXFP1 | |
| SCHEMBL18080548 | 0.75 | KDM4E (0.37) | KDM4EKMT2AOPRK1MAPTSMPD3 | |
| SCHEMBL16631941 | 0.74 | MAPT (0.32) | KDM4EKMT2AMAPTRXFP1ALDH1A1 | |
| SCHEMBL16631709 | 0.73 | NR1I3 (0.41) | KDM4EKMT2AMAPTRXFP1ALDH1A1 | |
| SCHEMBL18081949 | 0.70 | SMPD3 (0.35) | KDM4EMAPTSMPD3HIF1A | |
| SCHEMBL16631922 | 0.67 | L3MBTL1 (0.35) | KDM4EKMT2AOPRK1MAPTRXFP1 | |
| SCHEMBL18080542 | 0.66 | SMPD3 (0.32) | KDM4ESMPD3HIF1A | |
| SCHEMBL16631707 | 0.64 | KMT2A (0.31) | KMT2AMAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051173-A2 | POLYNUCLEOTIDE MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC (US) | 2015-04-09 | — | — | WO | disclosed |