Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 11/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16632860 | 0.87 | RORC (0.50) | RORC | |
| SCHEMBL15647927 | 0.84 | RORC (0.47) | CYP1A2CYP2D6CYP2C9CYP2C19RXFP1 | |
| SCHEMBL15648443 | 0.84 | RORC (0.53) | CYP1A2CYP2D6CYP2C9CYP2C19RXFP1 | |
| SCHEMBL15648218 | 0.83 | RORC (0.51) | CYP1A2CYP2D6CYP2C9CYP2C19RXFP1 | |
| SCHEMBL15648275 | 0.82 | CYP1A2 (0.52) | CYP1A2CYP2D6CYP2C9CYP2C19RXFP1 | |
| SCHEMBL12749514 | 0.81 | CYP1A2 (0.54) | CYP1A2CYP2D6CYP2C9CYP2C19RXFP1 | |
| SCHEMBL16461194 | 0.79 | NT5E (0.50) | CYP1A2CYP2D6CYP2C9CYP2C19RXFP1 | |
| SCHEMBL15647907 | 0.77 | CYP1A2 (0.47) | CYP1A2CYP2D6CYP2C9CYP2C19RXFP1 | |
| SCHEMBL16632857 | 0.77 | CYP2C19 (0.50) | CYP1A2CYP2D6CYP2C9CYP2C19RXFP1 | |
| SCHEMBL16651673 | 0.76 | CYP1A2 (0.54) | CYP1A2CYP2D6CYP2C9CYP2C19RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-11-20 | — | — | EP | disclosed |
| US-9284308-B2 | Methylene linked quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV | 2016-03-15 | — | — | US | disclosed |
| US-9284308-B2 | Methylene linked quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV | 2016-03-15 | — | — | US | disclosed |
| US-20150105366-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-16 | — | — | US | disclosed |
| US-20150105366-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-16 | — | — | US | disclosed |
| US-20150105366-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105366-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF RORyt | RORC, RORA, RORB | CYP1A2 841/4885CYP2D6 321/4885CYP2C9 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.