Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381692 | 0.82 | LMNA (0.46) | ALDH1A1TP53HIF1ALMNAMEN1 | |
| SCHEMBL12301466 | 0.82 | LMNA (0.46) | ALDH1A1TP53HIF1ALMNAMEN1 | |
| SCHEMBL2382559 | 0.79 | LMNA (0.54) | ALDH1A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL31661220 | 0.78 | ALDH1A1 (0.63) | ALDH1A1TP53HIF1ALMNAMEN1 | |
| SCHEMBL9064055 | 0.77 | ALDH1A1 (0.46) | ALDH1A1LMNAMEN1KMT2AGAA | |
| SCHEMBL3030037 | 0.76 | LMNA (0.60) | ALDH1A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL2382286 | 0.75 | SMN1; SMN2 (0.49) | ALDH1A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL10890401 | 0.75 | LMNA (0.54) | ALDH1A1LMNAMEN1KMT2ATDP1 | |
| SCHEMBL8101683 | 0.72 | GSK3B (0.42) | ALDH1A1HIF1ALMNAKMT2ASMN1; SMN2 | |
| SCHEMBL2552398 | 0.72 | LMNA (0.61) | ALDH1A1LMNAMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670197-B2 | Small molecule modifiers of the Hec1-Nek2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| US-9670197-B2 | Small molecule modifiers of the Hec1-Nek2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| US-9670197-B2 | Small molecule modifiers of the Hec1-Nek2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-06 | — | — | US | disclosed |
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-03 | — | — | US | disclosed |
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-11-03 | — | — | US | disclosed |
| US-9422275-B2 | Small molecule modifiers of the HEC1-NEK2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422275-B2 | Small molecule modifiers of the HEC1-NEK2 interaction in G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-16 | — | — | US | disclosed |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318918-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | NR2E1, NEK4, NCOR2 | ALDH1A1 3515/4885TP53 919/4885HIF1A 892/4885 |
| US-20150105391-A1 | SMALL MOLECULE MODIFIERS OF THE HEC1-NEK2 INTERACTION IN G2/M | NR2E1, NEK4, NCOR2 | ALDH1A1 3515/4885TP53 919/4885HIF1A 892/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.