Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | SPPL2B | Q8TCT7 | 1/20 | 0.37 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16633980 | 0.87 | ALDH1A1 (0.41) | MMP2MMP9ALDH1A1PDE2APOLB | |
| SCHEMBL16634078 | 0.86 | EPHX1 (0.40) | MMP2MMP9ALDH1A1PDE2ASLC6A2 | |
| SCHEMBL16633428 | 0.85 | ALDH1A1 (0.38) | MMP2MMP9ALDH1A1PDE2ASLC6A2 | |
| SCHEMBL16632995 | 0.84 | EPHX1 (0.41) | MMP2MMP9ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL16633307 | 0.82 | ALDH1A1 (0.38) | MMP2MMP9ALDH1A1PDE2APOLB | |
| SCHEMBL16633172 | 0.82 | ALDH1A1 (0.38) | MMP2MMP9ALDH1A1PDE2APOLB | |
| SCHEMBL16633119 | 0.80 | SLC6A4 (0.47) | SLC6A2SLC6A4OPRM1 | |
| SCHEMBL16633394 | 0.78 | ALDH1A1 (0.38) | ALDH1A1PDE2ASLC6A2SLC6A4EPHX1 | |
| SCHEMBL16563726 | 0.77 | TRPV1 (0.40) | ALDH1A1PDE2AEPHX1SERPINE1PSEN1 | |
| SCHEMBL16633600 | 0.77 | MMP2 (0.46) | MMP2MMP9ALDH1A1PDE2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9469637-B2 | Nitrogenated heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-10-18 | — | — | US | disclosed |
| US-20150105373-A1 | NITROGENATED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150105373-A1 | NITROGENATED HETEROCYCLIC COMPOUND | PDE2A, PDE5A, PDE3A | MMP2 860/4885MMP9 474/4885MMP1 763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.