Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 20/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16646133 | 0.86 | ALOX12 (1.00) | ALOX12ALOX15ALDH1A1LMNAGAA | |
| Vlx-1005 SCHEMBL16646023 | 0.86 | ALOX12 (1.00) | ALOX12ALOX15ALDH1A1LMNAGAA | |
| Vlx-1005 SCHEMBL29598551 | 0.86 | ALOX12 (1.00) | ALOX12ALOX15ALDH1A1LMNAGAA | |
| SCHEMBL18356856 | 0.85 | ALOX12 (1.00) | ALOX12ALOX15ALDH1A1LMNAGAA | |
| SCHEMBL16646065 | 0.85 | ALOX12 (1.00) | ALOX12ALOX15ALDH1A1LMNAGAA | |
| SCHEMBL18356880 | 0.85 | ALOX12 (0.84) | ALOX12ALOX15ALDH1A1LMNAGAA | |
| SCHEMBL16634463 | 0.83 | ALOX12 (1.00) | ALOX12ALOX15ALDH1A1LMNAGAA | |
| SCHEMBL30891484 | 0.83 | ALOX12 (1.00) | ALOX12ALOX15ALDH1A1LMNAGAA | |
| SCHEMBL16646110 | 0.83 | ALOX12 (1.00) | ALOX12ALOX15ALDH1A1LMNAGAA | |
| SCHEMBL16646082 | 0.82 | ALOX12 (1.00) | ALOX12ALOX15ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054936-B1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2023-10-18 | — | — | EP | disclosed |
| EP-3054936-B1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2023-10-18 | — | — | EP | disclosed |
| US-11274077-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2022-03-15 | — | — | US | disclosed |
| US-20200392077-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-12-17 | — | — | US | disclosed |
| US-20200392077-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-12-17 | — | — | US | disclosed |
| US-10752581-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2020-08-25 | — | — | US | disclosed |
| US-10752581-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2020-08-25 | — | — | US | disclosed |
| US-20190276395-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-09-12 | — | — | US | disclosed |
| US-20190276395-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-09-12 | — | — | US | disclosed |
| US-10266488-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2019-04-23 | — | — | US | disclosed |
| US-20170001955-A1 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase | THOMAS JEFFERSON UNIVERSITY | 2017-01-05 | — | — | US | disclosed |
| US-20170001955-A1 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase | THOMAS JEFFERSON UNIVERSITY | 2017-01-05 | — | — | US | disclosed |
| EP-3054936-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS | Eastern Virginia Medical School (US) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015054662-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO) BENZENESULFONAMIDE DERIVATIVES AS 12-LIPOXYGENASE INHIBITORS | EASTERN VIRGINIA MEDICAL SCHOOL (US) | 2015-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266488-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | ALOX12, ALOX15, ALOX15B | ALOX12 1/4885ALOX15 2/4885ALDH1A1 3051/4885 |
| US-20200392077-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE | ALOX12, ALOX15, ALOX15B | ALOX12 1/4885ALOX15 2/4885ALDH1A1 3051/4885 |
| US-11274077-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | ALOX12, ALOX15, ALOX15B | ALOX12 1/4885ALOX15 2/4885ALDH1A1 3051/4885 |
| US-20190276395-A1 | 4-((2-HYDROXY-3-METHOXYBENZYL)AMINO)BENZENESULFONAMIDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF 12-LIPOXYGENASE | ALOX12, ALOX15, ALOX15B | ALOX12 1/4885ALOX15 2/4885ALDH1A1 3051/4885 |
| US-10752581-B2 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase | ALOX12, ALOX15, ALOX15B | ALOX12 1/4885ALOX15 2/4885ALDH1A1 3051/4885 |
| US-20170001955-A1 | 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase | ALOX12, ALOX15, ALOX15B | ALOX12 1/4885ALOX15 2/4885ALDH1A1 3051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.