Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753289 | 0.86 | KEAP1 (0.46) | KEAP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23581891 | 0.84 | KDM4E (0.51) | KEAP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL18113432 | 0.81 | ALDH1A1 (0.49) | KEAP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1901160 | 0.80 | KDM4E (0.43) | KEAP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4942021 | 0.78 | CYP1A2 (0.50) | KDM4EALDH1A1HPGDTDP1GLA | |
| SCHEMBL600522 | 0.77 | KEAP1 (0.55) | KEAP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL239744 | 0.76 | ALDH1A1 (0.32) | ALDH1A1KMT2AMAPTMEN1PKM | |
| SCHEMBL9344625 | 0.76 | KEAP1 (0.50) | KEAP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL866073 | 0.74 | MMP2 (0.55) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL9671806 | 0.73 | TSHR (0.44) | ALDH1A1KMT2ATDP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |