Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.57 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16634650 | 1.00 | DHODH (0.57) | DHODHHCAR3MAPTKMT2AMEN1 | |
| SCHEMBL11847493 | 0.84 | MEN1 (0.57) | DHODHMAPTKMT2AMEN1NPC1 | |
| SCHEMBL16634858 | 0.81 | HCAR3 (0.63) | HCAR3MAPTKMT2AMEN1MAPK1 | |
| SCHEMBL16634860 | 0.81 | HCAR3 (0.63) | HCAR3MAPTKMT2AMEN1MAPK1 | |
| SCHEMBL11551932 | 0.79 | MEN1 (0.65) | MAPTKMT2AMEN1NPC1NFKB1 | |
| SCHEMBL16634619 | 0.79 | HCAR3 (0.53) | HCAR3MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL6798177 | 0.79 | KMT2A (0.65) | HCAR3MAPTKMT2AMEN1NPC1 | |
| SCHEMBL16634621 | 0.79 | HCAR3 (0.53) | HCAR3MAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL16634745 | 0.77 | ALDH1A1 (0.54) | HCAR3MAPTKMT2AMEN1RAB9A | |
| SCHEMBL16634742 | 0.77 | ALDH1A1 (0.54) | HCAR3MAPTKMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015052675-A1 | SUBSTITUTED DIHYDRO-BENZIMIDAZOLE COMPOUNDS AS ROR GAMMA MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-16 | — | — | WO | disclosed |